In addition to same-screen battles on a single console, the game supports multiplayer combat over the Internet, for Wi-Fi connected players across North America.
The game refines the fan-familiar control scheme and adds new and more powerful attacks and defensive maneuvers, as featured in the animated series Shippuden sequel. Building on the mechanics of earlier games in the series, Clash of Ninja Revolution III allows players to control their characters with the motion-sensitive Wii Remote and Nunchuk, or by using the more traditional Wii Classic controller or GameCube controller. In addition to one-off battles for quick, pick-up-and-play action, the game offers a single-player storyline mode that follows the plots of the comics and television series.